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A randomized, single-dose cross-over study in 32 postmenopausal women was performed to demonstrate bioequivalence of two estradiol valerate containing formulations (first sequence of Klimonorm as test preparation). The serum levels of estradiol, free and conjugated estrone were measured until 48 h after an oral dosage of 4 mg estradiol valerate (CAS… (More)
Using melatonin (MT) as a circadian synchroniser in humans to treat a variety of rhythm disorders, it is desirable to develop controlled-release dosage forms that deliver MT in accordance with its endogenous secretory pattern as well as preparations that release MT in a pulsatile way. In this paper we describe two oral pulsatile dosage forms containing 10… (More)
OBJECTIVE This randomized, double-blind, placebo-controlled study was planned to investigate the effects of continuous combined hormone replacement therapy (HRT) with 2 mg estradiol valerate and 2 mg dienogest (Climodien/Lafamme) over 24 weeks on postmenopausal depression. METHOD A total of 129 patients with a mild to moderate depressive episode according… (More)
The proceedings are published online on the CEUR-Workshop web site in a series with ISSN 1613-0073.
Zielsetzung Ziel des Workshops ist es, Akteure aus Hochschulen und (Weiter-)Bildungsinstitutionen zusammenzubringen und Erfahrungen und Untersuchungen zum Einsatz von Blended-Learning in Master-und Weiterbildungsangeboten zu teilen und zu diskutieren.