Hendrik Breitbarth

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Using melatonin (MT) as a circadian synchroniser in humans to treat a variety of rhythm disorders, it is desirable to develop controlled-release dosage forms that deliver MT in accordance with its endogenous secretory pattern as well as preparations that release MT in a pulsatile way. In this paper we describe two oral pulsatile dosage forms containing 10(More)
A randomized, single-dose cross-over study in 32 postmenopausal women was performed to demonstrate bioequivalence of two estradiol valerate containing formulations (first sequence of Klimonorm as test preparation). The serum levels of estradiol, free and conjugated estrone were measured until 48 h after an oral dosage of 4 mg estradiol valerate (CAS(More)
OBJECTIVE This randomized, double-blind, placebo-controlled study was planned to investigate the effects of continuous combined hormone replacement therapy (HRT) with 2 mg estradiol valerate and 2 mg dienogest (Climodien/Lafamme) over 24 weeks on postmenopausal depression. METHOD A total of 129 patients with a mild to moderate depressive episode according(More)
Im Kontext der systematischen Konzeption eines Weiterbildungsstudiengangs an der Bauhaus-Universität Weimar erfolgte die didaktische Implementierung eines Blended-LearningAngebots in die grundständige Lehre der Professur Marketing und Medien (N = 34 Studierende). Die Wissensvermittlung mittels verschiedener E-Learning-Tools und kombinierten(More)
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