Hemantkumar Deokar

Learn More
Disrupting the interaction between the PDZ protein, PSD-95, and its target ligands (such as the glutamate NMDA receptor or the serotonin 5-HT2A receptor) was found to reduce hyperalgesia in various models of neuropathic pain. Here, we set out to identify lead molecules which would interact with PSD-95, and hence, would potentially display analgesic(More)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain, fever and inflammatory diseases such as rheumatoid arthritis and osteoarthritis. A series of direct analogues of flurbriprofen [4'-methylbiphenyl-2-(substituted phenyl) carboxamide derivatives] have been reported as novel anti-inflammatory agent. In order to gain(More)
Various direct analogues of flurbriprofen [ 4'-methylbiphenyl-2-(substituted phenyl) carboxamide derivatives ] were synthesized and evaluated for anti-inflammatory activity by carrageenan induced rat paw edema model. Compounds 3g, 3h and 3i were found significantly active. Substituents –SO 2 NH 2 ,-F and-Cl exhibited significant anti-inflammatory activity.(More)
  • 1