Hemant B Badgandi

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Dynamic changes in membrane protein composition of the primary cilium are central to development and homeostasis, but we know little about mechanisms regulating membrane protein flux. Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in accumulation and activation of the effector Smoothened within cilia and concomitant disappearance of(More)
The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube, kidney, and brain. The primary cilium is the site where a subset of the cell's membrane proteins is enriched. However,(More)
The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting integral membrane proteins to cilia are poorly understood. In this study, we determine that the tubby family protein TULP3 functions as a general adapter for ciliary trafficking of structurally diverse(More)
We are proud to announce that Mike Kuhns, PhD, Assistant Professor, was recently notified by NIH of a 4-year R01 grant award for a total $1.5 million. Over the life of the grant, Dr. Kuhns and his lab personnel will be studying " Probing the mechanistic basis for T cell fate decisions. " As Dr. Kuhns explains it " [t]he TCR-CD3 complex, CD4, and CD28 are(More)
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