One hundred micrograms of ovine-corticotropin releasing factor (o-CRF) was administered intravenously to eight unmedicated patients with severe endogenous depression. Responses of immunoreactive (ir)-ACTH and the adrenal glucocorticosteroids corticosterone (B), 11-deoxycortisol (S), cortisol (F) and cortisone (E) were measured and compared with those… (More)
The 1 mg dexamethasone suppression test was used to assess pituitary-adrenal activity in 23 depressed patients and 8 healthy volunteers. At 1600h, after administration of the test dose of dexamethasone at 2300h, levels of cortisol, 11-deoxycortisol, and corticotropin were determined following a chromatographic extraction step applying highly specific… (More)
We report on monozygotic twins with different clinical phenotypes of X-linked adrenoleukodystrophy. At the age of 10 years both boys were neurologically asymptomatic. The first cranial magnetic resonance examination showed normal findings in the first twin and parietooccipital demyelination in the second. The latter developed behavioral problems 9 months… (More)
BACKGROUND Intrauterine growth restriction (IUGR) is thought to lead to fetal programming that in turn contributes to developmental changes of many organs postnatally. There is evidence that IUGR is a risk factor for the development of metabolic and cardiovascular disease later in life. A higher incidence of breast cancer was also observed after IUGR. This… (More)
A 13-year-old girl with Cushing's disease suffered a manic episode. An adenoma of the pituitary gland was found to be the cause. After the adenoma had been removed, the girl's condition returned to normal. The affective disorder was classified as an organic mood disorder (DSM-III-R).
The dexamethasone suppression test (DST) based on multisteroid analysis was administered to 22 female patients with primary major depressive disorder (12 endogenous, 10 nonendogenous) and 12 healthy control subjects. Cortisol, its biosynthetic precursor 11-deoxycortisol, and cortisone were measured. Calculating cortisol/11-deoxycortisol ratios allows the… (More)
Plasma ACTH levels after oral ingestion of 2 g metyrapone at 24.00 hours in six healthy subjects were higher after pretreatment with zimelidine (300 mg) in comparison to placebo. Since zimelidine is a relatively selective serotonin reuptake inhibitor its action on hypothalamic-pituitary-adrenal (HPA) activity suggests that serotonin is a potent stimulator… (More)
The dexamethasone suppression test based upon analysis of 11-deoxycorticosterone, corticosterone and cortisol was applied to 20 female depressed patients (10 endogenous, 10 neurotic) and 10 healthy controls. Calculating ratios of corticosterone to its biological precursor 11-deoxycorticosterone allows to assess the activity of adrenal 11 beta-hydroxylase.… (More)