Helmut Thiele

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The clinical features of Angelman syndrome (AS) comprise severe mental retardation, postnatal microcephaly, macrostomia and prognathia, absence of speech, ataxia, and a happy disposition. We report on seven patients who lack most of these features, but presented with obesity, muscular hypotonia and mild mental retardation. Based on the latter findings, the(More)
The course of plasma cortisol and beta-endorphin-like immunoreactivity (beta-EP-IR) was determined following a single i.v. administration of 20 mg naloxone. The test subjects included 20 male alcoholics (medication-free), investigated one to three days and four weeks after the onset of abstinence, as well as 10 short-time abstinent alcohol abusers and 10(More)
Two brothers with congenital microcephaly, growth and mental retardation, flexion contractures, dorsal edema of hands and feet, and ichthyotic skin changes are described. Mild manifestations of Neu-Laxova syndrome have to be considered but long survival and only mild intrauterine growth retardation not described in this syndrome may be evidence of a(More)
In developing a semantics for a Fuzzy If-Then Rule Base we in principle distinguish the following two approaches. Firstly, a Fuzzy If-Then Rule Base is considered as a Fuzzy Knowledge Base describing (time independent) situations by means of fuzzy logic. Secondly, a Fuzzy If-Then Rule Base describes the " inner part " of a fuzzy controller, therefore the(More)