Helmut Müller

Knut Beuerlein3
Oliver Dittrich-Breiholz2
3Knut Beuerlein
2Oliver Dittrich-Breiholz
2Daniela Kettner-Buhrow
2Heike Schneider
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Cytokines and stress-inducing stimuli signal through c-Jun N-terminal kinase (JNK) using a diverse and only partially defined set of downstream effectors. In this paper, the decapping complex subunit DCP1a was identified as a novel JNK target. JNK phosphorylated DCP1a at residue S315 in vivo and in vitro and coimmunoprecipitated and colocalized with DCP1a(More)
Histone deacetylase (HDAC) 3, as a cofactor in co-repressor complexes containing silencing mediator for retinoid or thyroid-hormone receptors (SMRT) and nuclear receptor co-repressor (N-CoR), has been shown to repress gene transcription in a variety of contexts. Here, we reveal a novel role for HDAC3 as a positive regulator of IL-1-induced gene expression.(More)
  • Holger Buss, Katja Handschick, Nadine Jurrmann, Pirita Pekkonen, Knut Beuerlein, Helmut Müller +6 others
  • 2012
Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylated p65 in vitro and in transfected cells. The physiological(More)
TAB1 was defined as a regulatory subunit of the protein kinase TAK1, which functions upstream in the pathways activated by interleukin (IL)-1, tumor necrosis factor (TNF), toll-like receptors (TLRs) and stressors. However, TAB1 also functions in the p38 MAPK pathway downstream of TAK1. We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel(More)
The purpose of the study was to test the hypothesis that myofiber recruitment is enhanced when whole-body vibration (WBV) is added to squat training. In a randomized cross-over design, 14 recreationally active men were subjected to 2 sessions consisting of 5 sets of 10 squats with external load, performed either on a vibration platform (whole-body vibration(More)
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