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Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC),(More)
Trimethyl-lysine (me3) modifications on histones are the most stable epigenetic marks and they control chromatin-mediated regulation of gene expression. Here, we determine proteins that bind these marks by high-accuracy, quantitative mass spectrometry. These chromatin "readers" are assigned to complexes by interaction proteomics of full-length(More)
High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A(More)
The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorporation properties. Z.2.2 mRNA is found(More)
We summarize the current status and future prospects for low energy (weak scale) supersymmetry. In particular, we evaluate the capabilities of various e + e ? , p p and pp colliders to discover evidence for supersymmetric particles. Furthermore, assuming supersymmetry is discovered, we discuss capabilities of future facilities to disentangle the anticipated(More)
The proposed International Linear Collider (ILC) is well-suited for discovering physics beyond the Standard Model and for precisely unraveling the structure of the underlying physics. The physics return can be maximized by the use of polarized beams. This report shows the paramount role of polarized beams and summarizes the benefits obtained from polarizing(More)
Analysis of the chargino and neutralino mass parameters at one–loop level Abstract In the Minimal Supersymmetric Standard Model (MSSM) the masses of the neutralinos and charginos depend on the gaugino and higgsino mass parameters M , M ′ and µ. If supersymmetry is realized, the extraction of these parameters from future high energy experiments will be(More)
One–loop corrections to the chargino and neutralino mass matrices in the on–shell scheme Abstract We present a consistent procedure for the calculation of the one–loop corrections to the charginos and neutralinos by using their on–shell mass matrices. The on– shell gaugino mass parameters M and M ′ , and the Higgsino mass parameter µ are defined by the(More)
We calculate the supersymmetric O(α s) QCD corrections to the decays˜q i → q ′ ˜ χ ± j (i, j = 1, 2) and˜q i → q ˜ χ 0 k (k = 1,. .. 4) within the Minimal Supersymmetric Standard Model. In particular we consider the decays of squarks of the third generation, ˜ t i and˜b i (i = 1, 2), where the left–right mixing must be taken into account. The corrections(More)