Hellen Karine Stulzer

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The poor solubility of drugs remains one of the most challenging aspects of formulation development. Aiming at improving the biopharmaceutical limitations of the calcium channel blocker nimodipine, the development of solid dispersions is proposed herein. Three different proportions of nimodipine:HPMC were tested and all of them generated amorphous solid(More)
Primaquine (PQ) is used for the radical cure of Plasmodium vivax malaria and can cause serious side effects in some individuals. The development of an extended-release dosage with poly(ethylene oxide) as a hydrophilic polymer has been investigated to improve drug efficacy and tolerability. The aim of this study was to evaluate in vivo a new extended-release(More)
Microparticles of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) containing resveratrol were successfully prepared by simple emulsion/solvent evaporation. All formulations showed suitable encapsulation efficiency values higher than 80%. PHBV microparticles revealed spherical shape with rough surface and presence of pores.(More)
Differential scanning calorimetry (DSC) with the support of Fourier transform infrared spectroscopy (FT-IR) was used as a screening technique for testing the compatibility of piroxicam (4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3carboxamide-1,1-dioxide) with various pharmaceutical excipients for solid dosage forms. Based on the results,(More)
This paper describes the antioedematogenic profile of marrubiin (1), the main constituent of Marrubium vulgare, a medicinal plant used in folk medicine of several countries to treat different pathologies. Compound (1) was analyzed in a model of microvascular leakage in mice ears. The results show that it exhibits significant and dose-related(More)
This article describes the optimization of a peel-off facial mask formulation. An investigation was carried out on the parameters of the formulation that most affect the desirable characteristics of peel-off facial masks. Cereal alcohol had a significant effect on the drying time at concentrations of 1–12% (w/w). The applicability of the evaluated(More)
Due to the physical-chemical and therapeutic impacts of polymorphism, its monitoring in raw materials is necessary. The purpose of this study was to develop and validate a quantitative method to determine the polymorphic content of nimodipine (NMP) raw materials based on differential scanning calorimetry (DSC). The polymorphs required for the development of(More)
The determination of nimodipine in the presence of its degradation products, formed through photolysis, acidic and alkaline hydrolysis, and the drug degradation kinetics under these conditions, was investigated through a validated liquid chromatography method. Separation was achieved using a Phenomenex Luna C18 column (250 × 4.6 mm i.d., 5 µm) with a mobile(More)
Monika P. Tagliari*, Gislaine Kuminek, Sílvia H. M. Borgmann, Charise D. Bertol e Simone G. Cardoso Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Bl. K, 88040-900 Florianópolis SC, Brasil Hellen K. Stulzer Departamento de Ciências Farmacêuticas, Universidade Estadual de Ponta Grossa, Campus(More)
The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however it depends on a suitable carrier selection. The work explored the use of the biopolymer sodium alginate (SA) as a potential carrier in solid dispersions (SD). The data demonstrated that SA was able to improve the(More)