Helle Hjorth Johannesen

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BACKGROUND The adrenal glucocorticoid stress response in humans causes catabolism, increasing blood glucose and heart rate, and possibly potentiates ischaemic damage to neurons. These effects could induce secondary brain damage in acute stroke. MATERIALS AND METHODS This prospective study was based on a single determination of s-cortisol in 172 patients(More)
BACKGROUND AND PURPOSE Although the causes of neurological deterioration in acute cerebral infarction have not yet been identified, many variables have been associated with deterioration. The aim of this study was to investigate deteriorating ischaemic stroke. METHODS Deterioration was defined as a decrease in Scandinavian Stroke Scale (SSS) of at least 2(More)
We compared morphologic computed tomography (CT)-based to metabolic fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT-based response evaluation in patients with metastatic colorectal cancer and correlated the findings with survival and KRAS status. From 2006 to 2009, patients were included in a phase II trial and treated with cetuximab and(More)
In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized (13)C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and (18)F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We have named this concept hyper PET. Intravenous injection of(More)
OBJECT Meningiomas in children are rare, infrequently described in the literature, and often associated with neurofibromatosis Type 2 (NF2). The authors report a series of 22 children treated for an intracranial meningioma in Denmark between 1935 and 1984. METHODS Of 1542 cases of pediatric intracranial tumors in children younger than 15 years of age, 22(More)
BACKGROUND Electrochemotherapy is a local anticancer treatment very efficient for treatment of small cutaneous metastases. The method is now being investigated for large cutaneous recurrences of breast cancer that are often confluent masses of malignant tumour with various degrees of inflammation. To this end 18-Flourine-Flourodeoxyglucose-Positron Emission(More)
In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect in all tumors.
Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed significant exercise related reduction in tumor incidence and growth across several tumor models including transplantable tumors (Lewis lung and(More)
Brown adipose tissue (BAT) is present in human adults and when present visualised with [ 18 F]-FDG PET. It contains large amounts of mitochondriae, which gives a higher water content compared to white adipose tissue and a high FDG avidity when activated [1]. Five adults underwent PET/MR. BAT was cold-activated using a water-perfused vest, with injection of(More)
The combination of PET with Diffusion Weighted Imaging (DWI) is a promising application of PET/MR. DWI geometric accuracy can be compromised in body regions with complex anatomy. Here, we assess DWI head/neck image quality following optimization of acquisition and post-processing. Preliminary data from 10 patients with cancer of the tonsil or base-of-tongue(More)
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