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Chromatin signatures of pluripotent cell lines
Epigenetic genome modifications are thought to be important for specifying the lineage and developmental stage of cells within a multicellular organism. Here, we show that the epigenetic profile ofExpand
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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promotersExpand
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Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes
Summary Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatalExpand
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Vascular smooth muscle cells in atherosclerosis
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the ‘response to injury’ and ‘vulnerable plaque’ hypotheses, contractileExpand
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A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
Rana et al. demonstrate that white adipose tissue-resident multipotent stromal cells (WAT-MSC) support IL-33– and LFA-1/ICAM-1–mediated proliferation and type-2 cytokine expression by ILC2.Expand
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Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
Vascular smooth muscle cells (VSMCs) show pronounced heterogeneity across and within vascular beds, with direct implications for their function in injury response and atherosclerosis. Here we combineExpand
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Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
Supplemental Digital Content is available in the text.
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The role of smooth muscle cells in plaque stability: Therapeutic targeting potential
Events responsible for cardiovascular mortality and morbidity are predominantly caused by rupture of “vulnerable” atherosclerotic lesions. Vascular smooth muscle cells (VSMCs) play a key role inExpand
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