Helle F. Jorgensen

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At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoietic system represents a powerful(More)
The epidermal growth factor (EGF) family and its receptors regulate normal and cancerous epithelial cell proliferation, a process that could be suppressed by anti-receptor blocking antibodies. Polypeptide elongation factor-1alpha (EF-1alpha) is a multifunctional protein whose levels are positively correlated with the proliferative state of cells. To(More)
The GC box is an important transcriptional regulatory element present in the promoters of many mammalian genes. In the present study we examine the effect of known GC-box-binding proteins on the promoter of the human elongation factor 1 A-1 (hEF1A-1) gene in human HeLa cells and Drosophila SL2 cells. In HeLa cells co-transfection with the GC-box-binding(More)
S05-01 Polycomb repressive complexes are required to maintain compact chromatin structure at Hox loci Ragnhild Eskeland, Duncan Sproul, Graeme Grimes, Shelagh Boyle, Martin Lieb, Clemence Kress, Nick Gilbert, Helle F. Jorgensen, Amanda G. Fisher, Arthur I. Skoultchi, Anton Wutz, Wendy A. Bickmore 1 University of Edinburgh, Edinburgh, United Kingdom 2(More)
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