Helle Evi Simovart

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Sepsis, being characterized by massive translocation of bacteria into tissues, induces the suppression of the function of both leukocytes and macrophages. The aim of the study was to count activated macrophages (AMs) and apoptotic (Ao) cells in the rat spleen during the period of experimental sepsis and to clarify the associations of these parameters with(More)
BACKGROUND Gram negative sepsis is reported to induce massive translocation of bacteria into tissues, which associates with decreased macrophage function and increased macrophage apoptosis. AIMS The objective of this study was to detect the translocation of bacteria into different organs and to evaluate macrophage activity and the apoptosis of macrophages(More)
The study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls. Women (n = 35) undergoing the excision of varicose veins were divided into 3 groups: younger than 35 years (I), 36-50 years (II), and older than 50 years (III). Apoptosis(More)
AIM Dysregulated apoptosis in the venous wall is believed to play important role in the onset and progression of human primary varicose veins. The aim of our study was to in situ investigate the apoptosis of endothelial cells (EC) and smooth muscle cells (SMC) together with the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular(More)
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