Hella Timmermann

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The aim of this study was to define the structural characteristics in a series of 21 analogues of the antihistaminergic drug diphenhydramine which are important for the interaction with cytochrome P-450. The compounds gave substrate (type I) binding spectra with rat hepatic microsomal cytochrome P-450. The main findings were: (1) two phenyl rings are needed(More)
Previous studies have shown that histamine H3 receptors may negatively control gastric acid secretion [1]. However, contrasting findings were reported depending on animal species, secretory stimulus and experimental model used. Various sites of action have been identified, including central and peripheral cholinergic neurons, enterochromaffin-like cells,(More)
An encapsulation/dehydration procedure was developed for Euglena gracilis Klebs as a 'model alga' to examine various cryoprotective regimes combined with controlled rate cooling to cryopreserve other Euglenoid taxa. Cryoprotective variables were optimised to enable reproducible growth following a combination of alginate encapsulation, sucrose osmotic(More)
Injections of histamine into the CNS produce powerful antinociception [1], but the role of the brain histaminergic system in pain relief has remained poorly understood. The periaqueductal grey (PAG), innervated by histaminergic neurons, is known to be an essential component of multiple, descending opioid and non-opioid pain-relieving systems which are(More)
The activation of prejunctionally-located histamine H3 receptors (H3Rs) reduces acetylcholine (ACh) release from the myenteric plexus and thus produces a negative control on the intestinal motility [1–3]. Based on this finding, isolated intestinal preparations are used to investigate effects mediated by peripheral H3Rs and to explore the actions of newly(More)
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