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Peptide-mediated protein delivery-which pathways are penetrable?
The growing number of reports on the effective cargo delivery by cell-penetrating peptides (CPPs) has extensively widened our knowledge about the mechanisms involved in CPP-mediated delivery.Expand
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Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity.
Cell-penetrating peptides (CPPs) are a promising group of delivery vectors for various therapeutic agents but their application is often hampered by poor stability in the presence of serum. DifferentExpand
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Adenosine–oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton
Aberrant regulation of protein kinases impairs normal cellular functioning and may lead to disease. The protein kinase involved in the regulation of the dynamics of the actin cytoskeleton, Rho‐kinaseExpand
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CPP-protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway.
The major limitation in the application of bioactive molecules is their low permeation across plasma membrane. Effective transporters - cell-penetrating peptides (CPPs) - are utilized to enhanceExpand
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Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction
Since their discovery, cell-penetrating peptides (CPPs) have provided a novel, efficient, and non-invasive mode of transport for various (bioactive) cargos into cells. Despite the ever-growing numberExpand
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Mapping of protein transduction pathways with fluorescent microscopy.
The number of various cargo delivered into cells by CPPs demonstrates the effective transport abilities of these short-peptidic sequences. Over the years of research, the translocation process ofExpand
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BISUBSTRAATNE INHIBIITOR ARC SURUB EFEKTIIVSELT MAHA RHO- KINAASIST LÄHTUVAID SIGNAALIRADASID RAKUKULTUURIS
SUMMARY Aberrant regulation of protein kinases impairs normal cellular functioning and may lead to disease. The protein kinase involved in the complex regulation of the dynamics of the actinExpand
Peptide and Protein Delivery with Cell-penetrating Peptides
Publisher Summary The most commonly used cell-penetrating peptides (CPPs): Tat, oligoarginine, and transportan, have all been demonstrated to facilitate the entry of protein/peptide cargoes intoExpand
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