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Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods reset genomic methylation, an epigenetic modification of DNA that influences gene expression, leading(More)
Progress in both speech and language processing has spurred efforts to support applications that rely on spoken—rather than written—language input. A key challenge in moving from text-based documents to such " spoken documents " is that spoken language lacks explicit punctuation and formatting, which can be crucial for good performance. This paper describes(More)
Generation of nanomechanical cantilever motion from biomolecular interactions can have wide applications, ranging from high-throughput biomolecular detection to bioactuation. Although it has been suggested that such motion is caused by changes in surface stress of a cantilever beam, the origin of the surface-stress change has so far not been elucidated. By(More)
Descriptive and geographic information system methods were used to depict the spatial and temporal characteristics of the outbreak of human infection with a novel avian influenza A(H7N9) virus in mainland China, the peak of which appeared between 28 March and 18 April 2013. As of 31 May 2013, there was a total of 131 reported human infections in China, with(More)
We have previously reported that neuropeptide Y (NPY), a sympathetic cotransmitter and vasoconstrictor, is mitogenic for vascular smooth muscle cells (VSMCs), and now report on the mechanisms mediating these effects. In rat aortic A10 cell line, NPY's potency was greater than that of norepinephrine, and efficacy similar to that of platelet-derived growth(More)
We describe a case-control study performed in Jiangsu, China, to evaluate risk factors for human infection with novel avian influenza A(H7N9) virus. Twenty-five cases and 93 controls matched by age, sex, and location were included in the study. Direct contact with poultry or birds in the two weeks before illness onset, chronic medical conditions(More)
Motivation: Development of tools for identification of new thioredoxin-fold proteins as well as other proteins belonging to superfamilies with low primary sequence conservation. Results: We present several algorithms for identifying thioredoxin (Trx)-fold proteins containing a conserved CxxC motif (two cysteines separated by two residues). The low(More)
  • Xiaoge Zeng, Miloš A Popovi´c, A P Dell´haye, O Schliesser, T Arcizet, R Wilken +164 others
  • 2014
We propose optimal designs for triply-resonant optical parametric oscillators (OPOs) based on degenerate four-wave mixing (FWM) in microcavities. We show that optimal designs in general call for different external coupling to pump and signal/idler resonances. We provide a number of normalized performance metrics including threshold pump power and maximum(More)
Vanadium dioxide (VO 2) is a promising reconfigurable optical material and has long been a focus of condensed matter research owing to its distinctive semiconductor-to-metal phase transition (SMT), a feature that has stimulated recent development of thermally reconfigurable photonic, plasmonic, and metamaterial structures. Here, we integrate VO 2 onto(More)
We demonstrate gigahertz electro-optic modulator fabricated on low temperature polysilicon using excimer laser annealing technique compatible with CMOS backend integration. Carrier injection modulation at 3 Gbps is achieved. These results open up an array of possibilities for silicon photonics including photonics on DRAM and on flexible substrates. A(More)