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COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
TLDR
In lung cancer cell lines and primary cells from a patient with lung cancer, cannabidiol elicited decreased viability associated with apoptosis and caused upregulation of COX-2 and PPAR-γ in tumor tissue and tumor regression that was reversible by GW9662. Expand
Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells
TLDR
Evidence for a hitherto unknown mechanism underlying the anti-invasive action of cannabidiol on human lung cancer cells is provided, suggesting a crucial role of PAI-1 in A549 invasiveness. Expand
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1
TLDR
The data indicate that cannabinoids induce ICAM‐1, thereby conferring TIMP‐1 induction and subsequent decreased cancer cell invasiveness, and cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1. Expand
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
TLDR
Findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers. Expand
Cancer Therapeutic Insights COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
The antitumorigenicmechanismof cannabidiol is still controversial. This study investigates the role of COX2 and PPAR-g in cannabidiol’s proapoptotic and tumor-regressive action. In lung cancer cellExpand