The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence.… (More)
Cancer Research UK Epidemiology Unit and Cancer Research UK Genotyping Facility, Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom; Cancer Research UK Molecular… (More)
Purpose: The influence of biophysical factors (drug metabolism, transport proteins, and chemical stability) on the cellular accumulation of camptothecin (CPT) and SN-38 was examined. Methods: Drug… (More)