Helga Ágústa Sigurjónsdóttir

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Acromegaly is a rare disease with complications and increased mortality. The incidence and prevalence of acromegaly worldwide is not well known. To gather information on patients diagnosed with acromegly in Iceland over 59 years. Information was retrospectively gathered about patients diagnosed with acromegaly from 1955 through 2013. Incidence was(More)
To clarify the dose-response and the time-response relationship between liquorice consumption and rise in blood pressure and explore the inter-individual variance this intervention study was designed and executed in research laboratories at University hospitals in Iceland and Sweden. Healthy, Caucasian volunteers who also served as a control for(More)
UNLABELLED BACKGROUND The existence of unilateral adrenal hyperplasia (AH) has been considered a rare cause of primary hyperaldosteronism (PA). METHODS In a prospective study we screened for PA in a non-selected (NSP) and selected hypertensive population (SP), to define the cause of PA. We included 353 consecutive patients with hypertension; age 20 to(More)
In this intervention study, we have investigated if hypertensive patients are more sensitive to liquorice-induced inhibition of 11 β-hydroxysteroid dehydrogenase (11 β-HSD) type 2 than normotensive (NT) subjects and if the response depends on gender. Healthy volunteers and patients with essential hypertension (HT), consumed 100 g of liquorice daily, for 4(More)
It is well known that excessive liquorice intake can induce sodium and fluid retention, hypokalaemia, hypertension and inhibition of the renin-angiotensin system. We tested whether regular moderate liquorice consumption (50 g and 100 g daily) raises blood pressure (BP) in a normotensive population. Ingestion of 100 g of liquorice daily (n = 30) caused a(More)
BACKGROUND incidentally detected adrenal lesions have become a growing clinical problem. PURPOSE to prospectively estimate and validate the prevalence of incidentally detected adrenal lesions (adrenal incidentaloma) in patients with or without malignant disease undergoing CT. MATERIAL AND METHODS during 18 months all adult patients with incidentally(More)
BACKGROUND This prospective cohort study investigated the incidence, clinical features and natural history of incidentally discovered adrenal mass lesions (adrenal incidentaloma, AI) in an unselected population undergoing radiological examination. METHODS During an 18-month period, all patients with AI were reported prospectively from all 19 radiology(More)
BACKGROUND AND OBJECTIVE Half a century ago the prevalence of Sheehan's syndrome (SS) was 10-20 per 100,000 women. With better obstetric help the prevalence is assumed to have decreased, especially in developed countries. The aim of this study is to estimate the prevalence of SS in modern times in Iceland. DESIGN We studied the prevalence of SS in 2009 in(More)
OBJECTIVE Liquorice-induced increase in blood pressure (BP) is more profound in subjects with essential hypertension (HT) than in healthy individuals. Liquorice induces pseudohyperaldosteronism by inhibiting the 11beta-hydroxysteroid dehydrogenase type 2 and is also known to inhibit the renin-angiotensin-aldosterone system (RAAS). We explored the difference(More)