Helena Kastarinen

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AIMS The demand for oral anticoagulant therapy will continue to increase in the future along with the aging of the population. This study aimed to determine the rate of bleeding requiring hospitalization and to characterize early bleeders among persons initiating warfarin therapy. Characterization of those most susceptible to early bleeding is important in(More)
BACKGROUND AND OBJECTIVE There are very few European cohort studies assessing the risk factors of end-stage renal disease (ESRD) in a community-based population. This study investigated the predictors of ESRD in Finland. DESIGN Prospective cohort study. SETTING Eastern Finland. SUBJECTS A random sample of 25,821 men and women aged 25-64 years from the(More)
CLINICAL QUESTION Are there differences in effectiveness between topical anti-inflammatory treatments (steroids, calcineurin inhibitors, or lithium salts) and placebo or azoles in the treatment of seborrheic dermatitis of the face and scalp in adults? BOTTOM LINE The topical anti-inflammatory treatments were more effective in achieving total clearance of(More)
PURPOSE The aim of this study was to examine the association between angiotensin converting enzyme (ACE) inhibitor use and the risk of acute pancreatitis. METHODS Information on all 4966 cases hospitalized in 2008-2010 for acute pancreatitis was retrieved from the Finnish national registers on hospital discharges and prescriptions. A total of 24 788 age(More)
OBJECTIVE Upper gastrointestinal bleeding (UGIB) is a common emergency, with in-hospital mortality between 3 and 14%. However, the long-term mortality and causes of death are unknown. We investigated the long-term mortality and causes of death in UGIB patients in a retrospective single-centre case-control study design. METHODS A total of 569 consecutive(More)
PURPOSE The aim of this research was to examine the association between statin use and the risk of acute pancreatitis. METHODS This register-based case-control study with incidence density sampling was based on 4376 patients hospitalized in 2008-2010 for acute pancreatitis and 19 859 randomly selected age and sex-matched controls from the adult population(More)
Patients' own views on medicines will grow in importance when trying to improve the quality of medicines use. Today, there is a general trend from paternalism towards concordance. Clarifying the patient's expectations and fears/worries is the first step in establishing a patient centered approach. A reserved attitude towards medicines is common, and(More)
OBJECTIVE The long-term use of statins may be associated with a decreased risk for gallstones and biliary-induced acute pancreatitis (AP). Our aim was to study the relationship of statin use and outcome of AP. METHODS We investigated the records of 461 consecutive patients with AP and 1140 patients with symptomatic gallstones during 2008 to 2010. The use(More)
OBJECTIVES The need to consider the patient perspective in health technology assessments (HTA) has been widely recognized. In July 2012, the Finnish Medicines Agency (Fimea) published a national recommendation for integrating the patient perspective into the HTAs of pharmaceuticals. The aim of this study is to describe the development of the recommendation(More)