Helena Kędzia

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Data indicates that genetic factors alone do not account for ovarian tumorigenesis, suggesting that epigenetic status additionally affects this process. Therefore, we assessed the possible contribution of polymorphic variants of genes that may affect DNA methylation to the risk of ovarian cancer incidence in the Polish population. Using PCR-RFLP and HRM(More)
Using nucleic acid hybridization and polymerase chain reaction (PCR) HPV-DNA sequence was detected in endometrial and ovarian carcinomas. This sequence was amplified with primer specific for E1 region of DNA-HPV 18 and hybridized with DNA-HPV 18. The presence of HPV-DNA in cancer studies suggests that human papillomavirus can also be involved in(More)
There were analysed prognostic factors in endometrial carcinomas. To essential prognostic factors were counted; proportion of cells in S-phase, DNA ploidy, proportion of Ki-67 positive cells and vascular invasion by cancer cells. All above-mentioned factors were not correlated to either the stage or the histopathologic subtype of the cancers. Application of(More)
INTRODUCTION Biophysics is becoming an important factor in prevention of cervical cancer. One of the most promising concepts of biophysical program for the prevention of cervical cancer is the optoelectronic method--Truscreen. OBJECTIVE The objective of the work was to determine the usefulness of the real optoelectronic device in the detection of cervical(More)
The development of cervical cancer requires genetic and epigenetic factors which result in the persistence of a malignant phenotype. Cervical cancer exhibits also some unique differences from other solid tumors. Normal cervical stratified epithelia have characteristics of hypoxic tissue with over-expression of HIF-1(More)
There are few publication in the literature on DNA HPV 16 in the lymph nodes of cervical cancer patients. Presence of HPV 16 in the lymph nodes is correlated with metastasis. Our investigation suggests that HPV 16 may be located in the lymph nodes without the presence of cancer cells.
OBJECTIVES Cervical cancer in Poland is second most common type of cancer, after breast cancer. There are known risk factors of cervical cancer development and the most serious one is human papilloma virus infection (HPV). DESIGN The aim of our paper is present the result study 414 cervical cancer of women from Wielkopolska region treated at the(More)
Germ cells development at particular stages of gonad differentiation during the period of fetal intrauterine life were investigated. The study was performed on 101 ovaries obtained from 76 fetuses and neonates. The earliest ovary obtained was from a 12-week old fetus, the oldest one was from a full-term fetus. The examination of germ cells was based on the(More)