Helena Elding Larsson

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In this study, we show that recombinant human histidine-rich glycoprotein (HRGP) has potent antiangiogenic properties as judged from effects on a syngeneic tumor model in C57/bl6 mice. Growth of fibrosarcoma, a very aggressive tumor, was reduced by >60% by HRGP treatment, and tumor angiogenesis was dramatically decreased. Treatment with HRGP led to(More)
" Diabetes associated HLA genotypes affect birth weight in the general population " Use of alternative location to go to the published version of the article requires journal subscription. Abstract: 246 Main text: 2880 3 Abstract Aims/hypothesis. The aim was to test the hypothesis that diabetes risk HLA-genotypes, cord blood autoantibodies or both are(More)
Genes and Immunity. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Access to the published version may require subscription. Sweden Study Group and the Better Diabetes Diagnosis Study group are listed in supplementary material. 4 Abstract The Major Histocompatibility Complex Class II(More)
OBJECTIVES To estimate the prevalence of self-rated musculoskeletal pain and pain limiting work ability in Swedish Armed Forces (SAF) marines, and to study factors potentially associated with pain limiting work ability for the most prevalent pain regions reported. DESIGN Population-based, cross-sectional survey. PARTICIPANTS There were 272 SAF marines(More)
BACKGROUND Early childhood environmental exposures, possibly infections, may be responsible for triggering islet autoimmunity and progression to type 1 diabetes (T1D). The Environmental Determinants of Diabetes in the Young (TEDDY) follows children with increased HLA-related genetic risk for future T1D. TEDDY asks parents to prospectively record the child's(More)
The objective of this study was to examine the content validity of commonly used muscle performance tests in military personnel and to investigate the reliability of a proposed test battery. For the content validity investigation, thirty selected tests were those described in the literature and/or commonly used in the Nordic and North Atlantic Treaty(More)
Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. This study used metabolomics to test if the cord-blood lipidome was affected in children diagnosed(More)
BACKGROUND We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD≤2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D susceptibility genes. METHODOLOGY/PRINCIPAL FINDINGS(More)
Test-retest reliability of neurophysiological tests of hand-arm vibration syndrome in vibration exposed workers and unexposed referents. muscle pathology after long-term vibration exposure. Lundborg G, Rosén B. The two-point discrimination test – time for a re-appraisal?. function tests and questions on hand symptoms as related to the Stockholm workshop(More)
BACKGROUND It is recognised that back pain (BP) is a debilitating medical problem in the soldier community, which limits operational readiness as well as work ability. As such, identification of risk factors is a necessity for effective preventive actions, but also regarded as important from a safety perspective. The aim of this prospective cohort study was(More)