Helen Rapley

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AG-045572 (CMPD1, 1 a) is a nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist that has been investigated for the treatment of sex hormone-related diseases. In the context of systematic studies on sila-substituted drugs, the silicon analogue disila-AG-045572 (1 b) and its derivative 2 were prepared in multi-step syntheses and characterized by(More)
Diabetic foot ulcers (DFUs) represent a disabling complication of diabetes that has a devastating impact on the quality of life and predict lower-limb amputation and premature mortality (1). Despite best practice, 30–40% of DFUs do not heal within 12–20 weeks (2). Novel therapeutic agents have been tested in clinical trials, and it has been estimated that(More)
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