Helen Owen

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Urothelial carcinoma of the bladder (UCC) is a common disease that arises by at least two different molecular pathways. The biology of UCC is incompletely understood, making the management of this disease difficult. Recent evidence implicates a regulatory role for microRNA in cancer. We hypothesized that altered microRNA expression contributes to UCC(More)
BACKGROUND Expert clinical judgement combines technical proficiency with humanistic qualities. AIMS To test the psychometric properties of questionnaires to assess the humanistic qualities of working with colleagues and relating to patients using multisource feedback. METHOD Analysis of self-ratings by 347 consultant psychiatrists and ratings by 4422(More)
BACKGROUND Countdown to 2015 was a multi-institution consortium tracking progress towards Millennium Development Goals (MDGs) 4 and 5. Case studies to explore factors contributing to progress (or lack of progress) in reproductive, maternal, newborn and child health (RMNCH) were undertaken in: Afghanistan, Bangladesh, China, Ethiopia, Kenya, Malawi, Niger,(More)
BACKGROUND Survivors of critical illness are at increased risk of fractures. This may be due to increased osteoclast formation during critical illness, leading to trabecular bone loss. Such bone loss has also been observed in Paget's disease, and has been related to deficient autophagy. Deficient autophagy has also been documented in vital organs and(More)
INTRODUCTION Blood transfusion in the perioperative period has frequently been associated with an excess of nosocomial infections. Whilst transfused whole blood induces specific host immune alteration that may predispose to nosocomial infections, the immunomodulating properties associated with leukodepleted blood remain incompletely understood. In this(More)
A flagellar A-Kinase anchoring protein with two amphipathic helices forms a structural scaffold in the radial spoke complex. 2012. DPY-30 domain and its flanking sequence mediate the assembly modulation of flagellar radial spoke complexes. 2012. The versatile molecular complex component LC8 promotes several distinct steps of flagellar assembly. 2008.(More)
Urothelial carcinoma of the bladder (UCC) is a common disease that arises by at least two different molecular pathways. The biology of UCC is incompletely understood, making the management of this disease difficult. Recent evidence implicates a regulatory role for microRNA in cancer. We hypothesized that altered microRNA expression contributes to UCC(More)
analysing country progress towards achieving Millennium Development Goals (MDGs) 4 (reduce child mortality) and 5 (improve maternal health), responding to The Lancet Child Survival Series [1]. For 12 years Countdown synthesised data on coverage and its key determinants across the continuum of care for women's and children's health, and regularly(More)