Helen M Rimington

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AIMS The aims of this study were to assess the accuracy of exercise testing in predicting symptom onset within 12 months in patients with asymptomatic aortic stenosis and to establish the criteria that define a positive test. METHODS AND RESULTS A total of 125 patients with aortic stenosis [effective orifice area (EOA) 0.9+/-0.2 cm2] were assessed by(More)
OBJECTIVE A stented bovine pericardial valve might be less obstructive than a stented porcine valve. This study compared early hemodynamic function in a prospective series of 99 patients randomized to receive either a Mosaic or Perimount replacement aortic valve. METHODS Echocardiography was performed early after surgery and at 1 year after surgery.(More)
BACKGROUND A stentless valve is expected to be hemodynamically superior to a stented valve. The aim of this study was to compare early postoperative hemodynamic function and clinical events in a randomized, prospective series of 160 stentless and stented biological replacement aortic valves. METHODS We randomized 160 consecutive patients on 1 surgeon's(More)
OBJECTIVE This study compared hemodynamic function and clinical events in consecutive patients randomly assigned to receive a wholly supra-annular replacement valve or a valve with an intra-annular component. METHODS Fifty-two patients with an average age of 62 years (range 40-74 years) were sized for both a CarboMedics Top Hat valve (CarboMedics Inc,(More)
BACKGROUND AND AIM OF THE STUDY There are many possible determinants of left ventricular (LV) mass, including the angiotensin-converting enzyme (ACE) genotype, which have rarely been compared in aortic stenosis (AS). The study aim was to investigate these determinants in patients with all grades of AS. METHODS Transthoracic echocardiography and an(More)
To compare the pressure drop/flow slope with peak and mean pressure drop, effective orifice area and aortic valve resistance for the prediction of symptom-onset we performed resting and dobutamine stress echocardiography in 49 asymptomatic patients with aortic stenosis (peak aortic velocity>2.5 m/s). The end-point was progression to symptoms requiring(More)
OBJECTIVES To test whether symptoms revealed on exercise testing in patients with moderate or severe aortic stenosis are associated with changes in left ventricular systolic function and to investigate the ability of resting measures to predict peak cardiac index. METHODS In a prospective study of asymptomatic aortic stenosis, 38 patients with a median(More)
AIMS Valve compliance might determine the onset of symptoms better than resting measures of aortic stenosis. This study compared valve compliance measured by dobutamine stress echocardiography with resting haemodynamic variables against the end-point of symptoms at low workload during exercise testing. METHODS AND RESULTS Echocardiography was performed at(More)