Helen J. Yang

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A primary expected benefit of object-oriented (OO) methods is the creation of software systems that are easier to adapt and maintain. OO design patterns are especially geared to improve adaptability, since patterns generally increase the complexity of an initial design in order to ease future enhancements. For design patterns to really provide benefit, they(More)
Intracerebral hemorrhage (ICH) usually affects older humans but almost no experimental studies have assessed aged animals. We address how aging alters inflammation, neuron death and lesion resolution after a hemorrhage in the rat striatum. In the normal aged brain, microglia displayed a 'dystrophic' phenotype, with shorter cellular processes and large gaps(More)
PURPOSE YKL-40 is a secreted protein that has been reported to be overexpressed in epithelial cancers and gliomas, although its function is unknown. Previous data in a smaller sample set suggested that YKL-40 was a marker associated with a poorer clinical outcome and a genetically defined subgroup of glioblastoma. Here we test these findings in a larger(More)
OBJECTIVE The aim of this study was to identify the influencing factors related to outcome of patients with hilar cholangiocarcinoma. METHODS From January 1999 to January 2009, 204 cases of hilar cholangiocarcinoma undergoing surgery were analyzed retrospectively. Bismuth-Corlette classification showed type I in 18 patients, type II in 40, type IIIa in(More)
BACKGROUND It has been reported previously that the combined loss of chromosomal arms 1p and 19q is a significant predictor of outcome for patients with anaplastic oligodendroglial (AO) tumors and that such chromosomal loss correlates with classic histology in AO. The authors sought to determine whether histology was an equivalent or superior predictor of(More)
During software evolution, adaptive, and corrective maintenance are common reasons for changes. Often such changes cluster around key components. It is therefore important to analyze the frequency of changes to individual classes, but, more importantly, to also identify and show related changes in multiple classes. Frequent changes in clusters of classes(More)
OBJECTIVE The purpose of our study was to investigate the association between green tea (Camellia sinensis) drinking habits and risk of stomach cancer in China. METHOD A 1:2 matched hospital-based case-control study including 160 cases and 320 controls was conducted. A self-designed questionnaire was used to collect information on possible risk factors of(More)
The Werner syndrome helicase (WRN) participates in DNA replication, double strand break repair, telomere maintenance, and p53 activation. Mutations of wrn cause Werner syndrome (WS), an autosomal recessive premature aging disorder associated with cancer predisposition, atherosclerosis, and other aging related symptoms. Here, we report that WRN is a novel(More)
OBJECTIVE The management of cholangiocarcinoma remains a challenge due to poor prognosis. The aim of this study was to identify the influencing factors related to outcome of patients with cholangiocarcinoma. METHODS From January 1999 to January 2009, 169 cases of cholangiocarcinoma undergoing surgery were analyzed retrospectively. Relationships between(More)
OBJECT In order to provide an updated quantification of the association between alcohol intake and colorectal cancer, we conducted a meta-analysis of published observational studies. METHOD Two cohort and 22 case-control studies presenting results for at least three categories of alcohol intake were identified from a PubMed search of articles published(More)