Helen J Trihia

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PURPOSE Expression of biomarkers in breast cancer, such as the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), can impact therapeutic decisions; however, it has been reported that their expression may change with disease progression. The aim of this retrospective study was to investigate the expression(More)
Osteosarcoma has been recognized for almost two centuries and is the most common primary, non-haemopoietic malignant tumour of the skeletal system. It is thought to arise from primitive mesenchymal bone-forming cells and its histologic hallmark is the production of osteoid. Other cell populations may also be present, as these types of cells may also arise(More)
BACKGROUND The aim of the present study was to investigate the efficacy of adjuvant dose-dense sequential chemotherapy with epirubicin, paclitaxel, and CMF in subgroups of patients with high-risk operable breast cancer, according to tumor subtypes defined by immunohistochemistry (IHC). MATERIALS AND METHODS Formalin-fixed paraffin-embedded (FFPE) tumor(More)
OBJECTIVE We present, for the first time, the cytological features of lymphoepithelioma-like carcinoma (LELC) of the breast in preoperative fine-needle aspiration (FNA) and touch imprints from secondary deposits in the sentinel lymph node (SLN). STUDY DESIGN We report a case of a 53-year-old woman who was diagnosed with breast carcinoma on preoperative(More)
BACKGROUND-AIM To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes. METHODS Cyclin E1, cyclin D1, p53, p21 and p27 were evaluated with immunohistochemistry in 1077 formalin-fixed paraffin-embedded tissues from breast cancer patients who had(More)
Peritoneal keratin granulomatosis is a rare condition included under granulomatous lesions of the peritoneum. It can be secondary to neoplasms of the female genital tract and can mimic carcinomatosis intraoperatively. A case of a 40-year-old woman with a history of polycystic ovaries and a chief complaint of vaginal bleeding is presented. She was diagnosed(More)
Solitary fibrous tumor (SFT) of the pleura is a rare neoplasm that arises most commonly within the visceral pleura but may evolve from the parietal pleura of the chest, mediastinum or diaphragm. These tumors are most commonly diagnosed in the 6th to 7th decade of life with equal rates of occurrence for both sexes. In this review we discuss the clinical,(More)
BACKGROUND Primary osteogenic sarcomas of the breast are extremely rare neoplasms. The histologic and cytologic features are comparable to those of their soft tissue and skeletal counterparts. To assess the utility of fine needle aspiration (FNA) in preoperative identification of osteogenic sarcomas, we retrospectively reviewed the FNA findings of 3 cases(More)
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