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BACKGROUND The short elimination half-life of hydromorphone necessitates 4-hourly dosing to maintain optimal levels of analgesia in patients with chronic cancer pain. The purpose of this study was to compare the clinical efficacy and safety of controlled release hydromorphone administered every 12 hours and immediate release hydromorphone administered every(More)
BACKGROUND Methadone is an effective treatment for opioid dependency and chronic pain. A methadone derivative, levacetylmethadol, was withdrawn from the European market after being associated with torsade de pointes. To date, no association between methadone and this arrhythmia has been described. OBJECTIVE To evaluate a series of methadone-treated(More)
Fentanyl has been incorporated into a transdermal therapeutic system (TTS) containing a rate-limiting membrane that provides constant release of the opioid. TTS fentanyl provides continuous opioid delivery for up to 72 hr without the need for special equipment. After Institutional Review Board approval, 53 patients with cancer pain requiring 45 mg or more(More)
Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used recently for analgesia in patients with chronic pain. Twenty one patients with chronic neuropathic pain were treated with oral ketamine starting at a divided dose of 100 mg/day and titrating upwards by 40 mg/day until efficacy was reached, or until side effects became(More)
PROBLEM BEING ADDRESSED About 65% of patients with advanced malignancies experience cancer pain. Although oral opioids provide effective analgesia for most of these patients, alternate routes of drug delivery are often necessary as the disease progresses. PURPOSE OF PROGRAM To study use of Duragesic (fentanyl transdermal system), the only transdermal(More)
OBJECTIVE To review use of gabapentin as an adjuvant agent to treat neuropathic pain. QUALITY OF EVIDENCE MEDLINE was searched from 1995 to October 1998 for reports. There were approximately 20 citations. Additional articles from Pain and other medical journals were reviewed. No double-blind studies have examined gabapentin and its use as an analgesic(More)
  • H Hays
  • 1985
Subcutaneous infusions of fluid and electrolytes can be used for replacement and correction of imbalance, by a method known as hypodermoclysis (HDC). Since April 1982, the Palliative Care Unit of the Edmonton General Hospital has been using this method for symptom control, titrating the rate of infusion against the severity of the symptoms, when the oral(More)