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The plasma membrane-associated enzyme NEU3 sialidase functions to cleave sialic acid residues from the ganglioside GM3 thereby promoting its degradation, and has been implicated in the modulation of insulin action. Herein, we report for the first time that impaired insulin sensitivity in skeletal muscle and liver of obese Zucker fatty rats and aged C57BL/6(More)
To the editor: In a recent issue of Nature Neuroscience, Floresco et al. elegantly demonstrate that afferents to the ventral tegmental area can differentially modify the firing patterns of dopamine neurons 1. They also report that the concentration of dopamine sampled by microdialysis during endogenous burst firing is similar to tonic firing unless dopamine(More)
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