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OBJECTIVE To determine the frequency of unexplained reversible hypoxemia in patients with systemic lupus erythematosus and to assess the relation between hypoxemia and elevated plasma levels of complement split products. DESIGN Cohort study. SETTING Inpatient and outpatient facilities of the New York University Medical Center/Bellevue Hospital and the(More)
I am the principal investigator for ACTG/NIH trials for the Chennai site. 1 Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. access to antiretroviral therapy may be the best approach to 'Do no harm' in developing countries: the Brazilian experience. The safety ,(More)
The recent recognition of the sleep apnea syndrome has forced a re-evaluation of the mechanism of hypercapnia and disordered respiratory control in obese patients. Thirteen obese patients with sleep apnea were studied in an attempt to relate the pattern of sleep abnormality and awake ventilatory control to the presence of chronic hypercapnia. Patients with(More)
The mechanisms of hypercapnia in eight patients with the "Pickwickian" syndrome and obstructive sleep apnea (OSAS) were evaluated pretherapy and posttherapy (tracheostomy in seven patients and chronic nocturnal use of nasal CPAP in one). Four patients (correctors) became eucapnic within two weeks of therapy. Four others (noncorrectors) remained hypercapnic.(More)
A case of sinusoidal fetal heart rate (FHR) pattern in association with maternal intrapartum administration of meperidine is presented. The sinusoidal pattern was reversed after maternal intrapartum administration of naloxone. The significance of this problem and the management of patients with sinusoidal FHR are discussed. The conclusion is reached that(More)
A study was designed to evaluate the diagnostic usefulness as well as the mechanical determinants of the flow-volume contour in chronic obstructive pulmonary disease (COPD). Twenty patients with COPD of varying etiology were divided equally into two groups. Group 1 had an airway collapse pattern (described in the text) designated type 1, and group 2 had a(More)
The strength of the evidence linking concurrency to HIV epidemic severity in southern and eastern Africa led the Joint United Nations Programme on HIV/AIDS and the Southern African Development Community in 2006 to conclude that high rates of concurrent sexual partnerships, combined with low rates of male circumcision and infrequent condom use, are major(More)
The Population Council is an international, nonprofit, nongovernmental organization that seeks to improve the well-being and reproductive health of current and future generations around the world and to help achieve a humane, equitable, and sustainable balance between people and resources. The Council conducts biomedical, social science, and public health(More)