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STIM1/Orai1-mediated SOCE: current perspectives and potential roles in cardiac function and pathology.

There is now substantial evidence that STIM1-mediated SOCE plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo, and there is growing support for the contribution of SOCE to Ca²⁺ overload associated with ischemia/reperfusion injury.
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Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

Studies reveal that BMAL1 influences metabolism, signaling, and contractile function of the heart, and reveals age-onset development of dilated cardiomyopathy in CBK mice, associated with a severe reduction in life span.
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Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.

It is demonstrated for the first time that STIM1 plays an essential role in normal cardiac function in the adult heart, which may be important for the regulation of ER and mitochondrial function.
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Inotropic Response of Cardiac Ventricular Myocytes to &bgr;-Adrenergic Stimulation With Isoproterenol Exhibits Diurnal Variation: Involvement of Nitric Oxide

The threshold for the development of arrhythmic activity in response to isoproterenol is higher during the active period of the rat, which is suggested to reflect a reduction in SR Ca2+ loading and a diurnal variation in neuronal NO synthase signaling.
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Protein O-GlcNAcylation and Cardiovascular (Patho)physiology*

The goals of this minireview are to summarize the current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O- GlcNAc cycling is critical for normal function of the cardiovascular system.
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Diurnal variation in excitation-contraction coupling is lost in the adult spontaneously hypertensive rat heart

The dip in response of the heart to ISO stimulation during the animal's active period is absent in adult SHRs, which may result from disruption to the circadian clock mechanism, which depresses the cycling of nNOS expression.
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O-GlcNAcylation and cardiovascular disease.

The goal of this review is to provide an overview of some of the more recent advances in the understanding of the role O-GlcNAcylation plays in mediating cardiovascular function and disease.
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Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism.

It is demonstrated, for the first time, that hearts lacking cardiomyocyte STIM1 exhibit dysregulation of both cardiac glucose and lipid metabolism, and this results suggest a potentially novel role forSTIM1 in regulating cardiac metabolism.
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Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy

An overview of the current usage of TEM to study cardiac ultrastructural changes is provided to understand how TEM aided the visualization of mitochondria, autophagy, and mitophagy under normal and cardiovascular disease conditions and the overall advantages and disadvantages are discussed.
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STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

The goal of this review is to describe the current understanding of the molecular regulation of STIM and Orai proteins and their roles in normal physiology and diseases of aging, with a particular focus on heart disease and neurodegeneration.
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