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Of the vertebrate senses, touch is the least understood at the molecular level The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However, the similarity of the brain sodium channel 1 (BNC1) to nematode proteins involved in mechanotransduction indicated that it might be a part of such a(More)
The molecular mechanisms underlying mechanoelectrical transduction and the receptors that detect light touch remain uncertain. Studies in Caenorhabditis elegans suggest that members of the DEG/ENaC cation channel family may be mechanoreceptors. Therefore, we tested the hypothesis that subunits of the mammalian epithelial Na(+) channel (ENaC) family are(More)
Mechanosensation is essential to the perception of our environment. It is required for hearing, touch, balance, proprioception, and blood pressure homeostasis. Yet little is known about the identity of ion-channel complexes that transduce mechanical stimuli into neuronal responses. Genetic studies in Caenorhabditis elegans suggest that members of the(More)
The molecular mechanisms underlying mechanoelectrical transduction and the receptors that detect light touch remain uncertain. Studies in Caenorhabditis elegans suggest that members of the DEG / ENaC cation channel family may be mechanoreceptors. Therefore, 1 we tested the hypothesis that subunits of the mammalian epithelial Na channel (ENaC) family are(More)
" The challenge is to convert humanness from being the destroyer of nature and productivity to being the supporter of nature, the sensitive gardener, the caring mother or husbandman. " —Frank B. Golley in A Primer for Environmental Literacy, 1998 Long lasting solutions emerging from natural resource management recognize the need for a balance between(More)
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