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The aims of the study were to provide valid comparative data for personal exposures to dust and endotoxins for different occupations and to calculate comparative data for the contamination of organic dusts with endotoxin. Nine different occupational settings were studied, drawn from the textile, agricultural and animal handling industries. Samples were(More)
BACKGROUND Many environmental factors have been investigated to determine their involvement in the asthma epidemic. OBJECTIVE We sought to investigate the indoor environment of English children. METHOD The Indoor Pollutants, Endotoxin, Allergens, Damp and Asthma in Manchester (IPEADAM) study recruited 200 asthmatic and age-, sex-, and sibship(More)
BACKGROUND Exposure and sensitization to indoor allergens is a major cause of asthma. OBJECTIVES This study investigated the levels of house dust mite, cat, dog and cockroach allergens in the dust and air in hospitals and the effects of regular vacuum cleaning on allergen levels in hospital chairs. METHODS Der p 1, Fel d 1, Can f 1 and Bla g 2 were(More)
BACKGROUND House dust mite allergens play an important role in inducing IgE-mediated sensitization and the development of bronchial hyperresponsiveness (BHR) and asthma. This study investigated the relationship between mite allergen exposure and the clinical activity and severity of asthma. METHODS Nonsmoking adult patients with asthma (n = 53) were(More)
BACKGROUND Despite medical advice, many pet-allergic asthma sufferers refuse to remove the pet to which they are sensitized from their home. OBJECTIVE We aimed to assess the clinical effects of air cleaners in the homes of adult asthma patients sensitized and exposed to cats and/or dogs. METHODS We performed a randomized, parallel-group study of 30(More)
The purpose of the study was to determine if exhaled nitric oxide levels in children varied according to their asthmatic and atopic status. Exhaled nitric oxide was measured in a sample of 93 children attending the North West Lung Centre, Manchester, United Kingdom, for the clinical evaluation of a respiratory questionnaire being developed as a screening(More)
UNLABELLED Children spend increasing time indoors. Exposure to environmental factors may contribute to the development or exacerbation of the asthmatic phenotype. Inter-relationships between these factors might influence the manifestation of asthma. Endotoxin exposure has been shown to have pro-inflammatory and protective effects in different situations. We(More)
BACKGROUND The prevalence of asthma and atopic disease has increased in recent decades, but precise reasons for this increase are unknown. BCG vaccination is thought to be among a group of vaccines capable of manipulating the immune system toward T(H)1 dominance and therefore reducing the likelihood of atopic disease. OBJECTIVE The aim of this study was(More)
BACKGROUND Allergen avoidance is of considerable interest in the treatment and even prevention of asthma. Attempts to control house dust mites have included environmental manipulation in homes in an attempt to reduce humidity below a level that favors mite survival. This appears to have some benefit in Scandinavia, but a previous attempt with mechanical(More)
OBJECTIVES To find the nature and incidence of symptoms experienced by a large sample of hospital endoscopy nurses. To find whether nurses in endoscopy units develop asthma under current working conditions in endoscopy units. To obtain analytically reliable data on exposure concentrations of glutaraldehyde (GA) vapour in endoscopy units, and to relate them(More)