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The 1.85 A crystal structure of endonuclease III, combined with mutational analysis, suggests the structural basis for the DNA binding and catalytic activity of the enzyme. Helix-hairpin-helix (HhH) and [4Fe-4S] cluster loop (FCL) motifs, which we have named for their secondary structure, bracket the cleft separating the two alpha-helical domains of the(More)
Clostridium difficile is a major and growing problem as a hospital-associated infection that can cause severe, recurrent diarrhea. The mechanism by which the bacterium colonizes the gut during infection is poorly understood but undoubtedly involves protein components within the surface layer (S-layer), which play a role in adhesion. In C. difficile, the(More)
Microorganisms were discovered in clouds over 100 years ago but information on bacterial community structure and function is limited. Clouds may not only be a niche within which bacteria could thrive but they might also influence dynamic processes using ice nucleating and cloud condensing abilities. Cloud and rain samples were collected from two mountains(More)
The interest in bioaerosols has traditionally been linked to health hazards for humans, animals and plants. However, several components of bioaerosols exhibit physical properties of great significance for cloud processes, such as ice nucleation and cloud condensation. To gain a better understanding of their influence on climate, it is therefore important to(More)
Infection with the bacterium Clostridium difficile causes symptoms ranging from mild to severe diarrhoea with life-threatening complications and remains a significant burden to healthcare systems throughout the developed world. Two potent cytotoxins, TcdA and TcdB are the prime mediators of the syndrome and rapid neutralisation of these would afford(More)
Ice-nucleation negative fluorescent pseudomonads isolated from Hebridean cloud and rain water produce biosurfactants H. E. Ahern, K. A. Walsh, T. C. J. Hill, and B. F. Moffett University of East London, Romford Road, Stratford, London, UK Environment Agency, Wallingford, UK Received: 1 September 2006 – Accepted: 15 September 2006 – Published: 4 October 2006(More)
Microbiology and atmospheric processes: biological, physical and chemical characterization of aerosol particles D. G. Georgakopoulos, V. Després, J. Fröhlich-Nowoisky, R. Psenner, P. A. Ariya, M. Pósfai, H. E. Ahern, B. F. Moffett, and T. C. J. Hill Agricultural University of Athens, Athens, Greece Max Planck Institute for Chemistry, Mainz, Germany Johannes(More)
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