Heinz Kruse

Learn More
In articles about the analysis of intraocular silicone oil, mostly the amount and toxicity of low-molecular-weight components (LMWC) have been investigated. This study was intended to analyze the components of silicone oil following a longer intraocular application. We analyzed silicone oil removed from human eyes with PVR a few months postoperatively. The(More)
Methods have been devised whereby the persistence of foreign antigens in mice can be detected. A highly diffusible, blue azo dye, echt-säure-blau was coupled to bovine gamma-globulin and human serum albumin and injected into the animals. In this way deep blue tracer antigens were obtained. These were promptly stored in cells widely distributed throughout(More)
Pronounced vascular changes occurring in the ears and claws of mice during anaphylactic shock are described. Practically at once after a foreign serum (pig, horse, or rabbit) enters the blood stream of sensitized animals both the arterial and venous vessels undergo marked, local or generalized constriction in the organs mentioned. Usually spasm of the(More)
Previous studies from this laboratory (1, 2) have indicated that certain foreign protein antigens, among them bovine "y-globulin, injected into the blood stream of mice, may persist in the blood for about 8 weeks and in certain tissues for nearly 14 weeks. I t is to be recalled that the detection of minute traces of antigen, persisting in the blood or(More)
Intraventricular injection of arginine-8-vasopressin and its analogues vasotocin and lysine-8-vasopressin into rat brain evoked a special rotational behavior resembling somatostatin-induced barrel rotation [1]. Oxytocin and oxypressin were less active while vasopressin fragments had no effect. Vasopressin-induced barrel rotation was accompanied by(More)
Three major metabolites (M1, M2, M3) of nomifensine (8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl-isoquinoline) are formed by hydroxylation and methoxylation of the phenyl ring. They were compared with nomifensine 1. in various psychopharmacological tests in vivo, carried out in mice after oral or i.p. treatment and 2. in neurochemical in vitro studies,(More)
A sensitive biological test has been used to detect the persistence of minute traces of a foreign protein, bovine gamma-globulin, in the blood and livers of rabbits intravenously injected with it, as an antigen. At various intervals after injecting these rabbits (donors) serum or liver tissue was transferred from them to the peritoneal cavities of normal or(More)
Intensely blue dye-azoproteins have been prepared by diazotization and coupling of the highly indiffusible blue dye T-1824, Evans blue, with various serum proteins and egg albumin. The products, whether purified by precipitation with alcohol or by chromatography, have a constant dye-to-protein ratio and tests have shown them to be essentially free from(More)
In previous work (1) the observation was made tha t some azoproteins injected intravenously into mice were still antigenic after storage in certain cells for several days. Exper iments have since been undertaken to learn how long azoproteins or the nat ive proteins from which they were derived can persist as antigens in the blood and tissues of mice. The ma(More)
  • 1