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We sought design principles for a vaccine to prevent HIV transmission to women by identifying correlates of protection conferred by a highly effective live attenuated SIV vaccine in the rhesus macaque animal model. We show that SIVmac239Δnef vaccination recruits plasma cells and induces ectopic lymphoid follicle formation beneath the mucosal epithelium in(More)
Conceptually, one antibody could be directed against a combining site structure of another antibody; thus, the two antibodies would combine with each other and might be considered at least partially complementary. Since the combining regions of antigen receptors on B lymphocytes are apparently identical with the combining regions of the antibodies that the(More)
A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain(More)
A rare type of antibody that spontaneously binds to each self (homodimerizes) has been described. This self-binding (autophilic) antibody provides stronger protection against bacterial infection than a non self-binding antibody with identical specificity and affinity due to increase of polymeric avidity. A peptide derived from the self-binding domain of the(More)
Live SIV vaccine correlate of protection: immune complex-inhibitory Fc receptor interactions that reduce target cell availability" (2014). Virology Papers. Paper 313. Abstract Principles to guide design of an effective vaccine against HIV are greatly needed, particularly to protect women in the pandemic's epicentre in Africa. We have been seeking these(More)
The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of(More)
In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies(More)
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