Heinrich Meier

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Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1).(More)
The need for in silico characterization of HTS hit structures as part of a data-driven hit-selection process is demonstrated. A solution is described in the form of an in silico ADMET traffic light and PhysChem scoring system. This has been extensively validated with in-house data at Bayer, published data, and a collection of launched small-molecule oral(More)
Mice. The same strains were used in our previous studies of the teratogenic effects of ENU, i.e., AKR/J, SWR/J, DBA/2J, C57BL/6J, and C57L/J. They were mated at approximately 10 weeks of age. The females were observed daily for vaginal plugs and palpated to determine preg nancy. The day that vaginal plugs were found was recorded as Day 0. Treatment Schedule(More)
Drug-like and lead-like hits derived from HTS campaigns provide good starting points for lead optimization. However, too strong emphasis on potency as hit-selection parameter might hamper the success of such projects. A detailed absorption, distribution, metabolism, excretion and toxicology (ADME-Tox) profiling is needed to help identify hits with a minimum(More)
Mice given quercetin per os at concentrations that were about 10(3) times greater than the estimated average human intake of total flavonols were tested for mutagenicity with 2 complementary in vivo mutagenicity/carcinogenicity screening tests--the micronucleus test and the host-mediated assay employing the Ames Salmonella tester strain TA 98 as indicator(More)