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e15060 Background: Integrins are cell surface receptors contributing to tumor progression by increasing cell migration, invasion, proliferation, and survival. DI17E6 (EMD 525797) is a de-immunized(More)
231 Background: EMD 525797 is a humanized monoclonal IgG2 antibody specifically targeting αv integrins involved in tumor progression. METHODS The safety, tolerability, pharmacokinetics (PK), and(More)
BACKGROUND EMD 525797 (DI17E6) is a deimmunized, humanized monoclonal immunoglobulin G2 antibody against the αv subunit of human integrins. Blocking αv integrins may be an effective strategy for(More)
231 Background: EMD 525797 is a humanized monoclonal IgG2 antibody specifically targeting αv integrins involved in tumor progression. METHODS The safety, tolerability, pharmacokinetics (PK), and(More)
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