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Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis…

• D. Sean Riminton, Heinrich Körner, Deborah H. Strickland, Frances A. Lemckert, John David Pollard, Jonathon D. Sedgwick
• The Journal of experimental medicine
• 1998

Lymphotoxin (LT) is widely regarded as a proinflammatory cytokine with activities equivalent to tumor necrosis factor (TNF). The contribution of LT to experimental autoimmune encephalomyelitis (EAE)… (More)

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

• Sigrid R. Ruuls, Robert M. Hoek, +9 authors Jonathon D. Sedgwick
• Immunity
• 2001

Mice without secreted TNF but with functional, normally regulated and expressed membrane-bound TNF (memTNF(Delta/Delta) mice) were created by knocking-in the uncleavable Delta 1-9,K11E TNF allele. In… (More)

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

• Heinrich Körner, D. Sean Riminton, Deborah H. Strickland, Frances A. Lemckert, John David Pollard, Jonathon D. Sedgwick
• The Journal of experimental medicine
• 1997

Tumor necrosis factor (TNF)-dependent sites of action in the generation of autoimmune inflammation have been defined by targeted disruption of TNF in the C57BL/6 mouse strain. C57BL/6 mice are… (More)

Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.

• Heinrich Körner, Marty Cook, +6 authors Jonathon D. Sedgwick
• European journal of immunology
• 1997

Specialized roles for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice established by direct gene targeting of… (More)

Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF.

• Patricia Brady Wilhelm, Uwe Ritter, +4 authors Heinrich Körner
• Journal of immunology
• 2001

The resolution of infections with the protozoan parasite Leishmania major in mice requires a Th1 response that is closely associated with the expression of IL-12, IFN-gamma, and inducible NO… (More)

CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis.

• Uwe Ritter, Anja Meissner, Christina Scheidig, Heinrich Körner
• European journal of immunology
• 2004

In the early phase of leishmaniasis three types of potential antigen-presenting cells, including epidermal Langerhans cells (LC), dermal dendritic cells (DC) and inflammatory DC, are localized at the… (More)

Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis.

• Uwe Ritter, Heinrich Körner
• Parasite immunology
• 2002

Human leishmaniasis is caused by protozoan Leishmania (L.) parasites and comprises a heterogeneous group of clinical appearances ranging from visceral to cutaneous leishmaniasis. In the New World, L.… (More)

Tumor necrosis factor: a master-regulator of leukocyte movement.

• Jonathon D. Sedgwick, D. Sean Riminton, Jason G Cyster, Heinrich Körner
• Immunology today
• 2000

TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis.

• Simona Virna, Martina Deckert, +6 authors Dirk Schlueter
• Journal of immunology
• 2006

Cerebral listeriosis is a life-threatening disease. However, little is known about the bacterial virulence factors responsible for the severe course of disease and the factors of the immune system… (More)

Cognitive dysfunction in mice deficient for TNF- and its receptors.

• Bernhard T. Baune, Florian Wiede, Anja K Braun, Jonathan Golledge, Volker Arolt, Heinrich Körner
• American journal of medical genetics. Part B…
• 2008

Recent evidence suggests a role for tumor necrosis factor alpha (TNF) in the functioning of the central nervous system (CNS). The aim of this work was to examine the effect of a deficiency of TNF… (More)

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