Heiner Schäfer

Susanne Sebens8
Ole Helm3
Bence Sipos3
8Susanne Sebens
3Ole Helm
3Bence Sipos
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BACKGROUND The L1 cell adhesion molecule (L1CAM) was originally identified as a neural adhesion molecule involved in axon guidance. In many human epithelial carcinomas L1CAM is overexpressed and thereby augments cell motility, invasion and metastasis formation. L1CAM positive carcinomas are associated with bad prognosis. Recent data point out that L1CAM is(More)
Nrf2 has gained great attention with respect to its pivotal role in cell and tissue protection. Primarily defending cells against metabolic, xenobiotic and oxidative stress, Nrf2 is essential for maintaining tissue integrity. Owing to these functions, Nrf2 is regarded as a promising drug target in the chemoprevention of diseases, including cancer. However,(More)
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a central role in inflammatory disorders. Transmembrane TNF-alpha and its two receptors are cleaved by the proteinase TNF-alpha converting enzyme (TACE), resulting in appreciable serum levels of soluble TNF-alpha and soluble TNF-alpha receptors (sTNFR1 and -2). The only known(More)
For a rapid induction and efficient resolution of the inflammatory response, gene expression in cells of the immune system is tightly regulated at the transcriptional and post-transcriptional level. The control of mRNA translation has emerged as an important determinant of protein levels, yet its role in macrophage activation is not well understood. We(More)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive stroma being also present in chronic pancreatitis (CP). Using immunohistochemistry, the stroma of CP and PDAC was comprehensively analyzed and correlated with epithelial/carcinoma-related alterations and clinicopathological patient characteristics. While there were no significant(More)
Besides genetic alterations in sporadic colon cancer, the persistent inflammation during inflammatory bowel diseases (IBD) is regarded as another high-risk factor of colorectal cancer (CRC). Accordingly, the inflammatory microenvironment being characterized by an elevated number of lamina propria macrophages has a pivotal role in colorectal carcinogenesis.(More)
  • Geeske Genrich, Marcus Kruppa, Lennart Lenk, Ole Helm, Anna Broich, Sandra Freitag-Wolf +4 others
  • 2016
Nuclear factor E2 related factor-2 (Nrf2) is an oxidative stress inducible transcription factor being essential in regulating cell homeostasis. Thus, acute induction of Nrf2 in epithelial cells exposed to inflammation confers protection from oxidative cell damage and mutagenesis supporting an anti-tumorigenic role for Nrf2. However, pancreatic ductal(More)
  • Sarah Arfmann-Knübel, Birte Struck, Geeske Genrich, Ole Helm, Bence Sipos, Susanne Sebens +2 others
  • 2015
Nrf2 and TGF-β1 both affect tumorigenesis in a dual fashion, either by preventing carcinogen induced carcinogenesis and suppressing tumor growth, respectively, or by conferring cytoprotection and invasiveness to tumor cells during malignant transformation. Given the involvement of Nrf2 and TGF-β1 in the adaptation of epithelial cells to persistent(More)
Data from genetically engineered mouse models as well as from epidemiological studies indicate that the immune system with active T-effector cells (T-effs) serves as a fundamental barrier to prevent the onset and progression of neoplastic disease. However, the fact that tumors nonetheless develop, despite intact immunity and the enrichment of immune cells(More)