Heimo Müller

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B iobanks 1 are well-organized repositories of biological material. They have become the fundamental resource for advancing medical research and constitute a major component of more generally understood bioresources. Yet they face a number of challenges to become more utilized on the national and global scale. These challenges range from fragmentation of(More)
Keratin 8 (K8) and keratin 18 (K18) form the major hepatocyte cytoskeleton. We investigated the impact of genetic loss of either K8 or K18 on liver homeostasis under toxic stress with the hypothesis that K8 and K18 exert different functions. krt8⁻/⁻ and krt18⁻/⁻ mice crossed into the same 129-ola genetic background were treated by acute and chronic(More)
This paper presents multilevel data glyphs optimized for the interactive knowledge discovery and visualization of large biomedical data sets. Data glyphs are three- dimensional objects defined by multiple levels of geometric descriptions (levels of detail) combined with a mapping of data attributes to graphical elements and methods, which specify their(More)
This paper presents a visual data mining approach using the combination of clinical data, pathways and gene-expression data. The visual exploration of medical data using pathways to navigate and filter the data allows a more systematic and efficient investigation of problems in modern life science. A multiplicity of hypothesis can be evaluated in the same(More)
Researches in humanities and social sciences indicate that people using more visual information would be more creative and benefit from the power of the human mind to a higher degree. Therefore information should not only be recorded as static text. It is rather conceivable to construct new visual languages that are not based on letters but on icons. We(More)
The eukaryotic translation initiation factor eIF3a is one of the core subunits of the translation initiation complex eIF3, responsible for ribosomal subunit joining and mRNA recruitment to the ribosome. It is known to play an important role in general translation initiation as well as in the specific translational regulation of various gene products, among(More)
As a hub of information controlled by the patient, personal health records (PHR) collect information from the patient medical history including a wide variety of data sources as patient's observations, lab results, clinical findings and in the future maybe even personal genetic data and automatic recordings from monitoring devices. This development will on(More)