Heiko von Goessel

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OBJECTIVE Molecular identification and clinical characterization of genetic mutations in patients with X-linked chronic granulomatous disease (CGD). PATIENTS AND METHODS Genomic DNA from 17 male patients with proven X-linked CGD based on clinical history, clinical examination, and specific granulocyte function tests were amplified by polymerase chain(More)
Ankylosing spondylitis (AS) is an inflammatory systemic disease affecting the spine, sacroiliacal and peripheral joints. Although the aetiology of AS remains unknown, the strong association with the HLA-B27 allele might reflect directly a detrimental effect of the HLA-B27 molecule itself, resulting from its potential capability to present 'arthritogenic'(More)
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