Heiko Ziegler

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OBJECTIVE To evaluate the metastatic risk of pT1 G2 squamous cell carcinoma (SCC) of the penis. PATIENTS AND METHODS We retrospectively reviewed 20 patients with pT1 G2 penile SCC and determined their groin status at first presentation, their nodal status after inguinal lymph node dissection and their follow-up for at least 18 months. RESULTS Four of(More)
Der hohe Stellenwert gebrauchstaugli-cher Benutzungsschnittstellen wird von immer mehr Unternehmen erkannt und erfordert eine Anpassung verbreiteter Vorgehensweisen bei der Anforderung-sermittlung und Systemspezifikation. Der Auftraggeber kann sich nicht darauf beschränken, die System-und Benut-zeranforderungen zu definieren. Der Auftragnehmer ist oft nicht(More)
The enhancement of valvular interstitial cell (VIC) calcification by transforming growth factor-β1 (TGF-β1) and the endothelial inducing effect of vascular endothelial growth factor (VEGF) have been demonstrated. Here we report the modulating properties of extracellular matrix (ECM) modification on VIC calcification in the presence of TGF-β1 and VEGF. Ovine(More)
Cell-matrix interactions in a three-dimensional (3D) extracellular matrix (ECM) are of fundamental importance in living tissue, and their in vitro reconstruction in bioartificial structures represents a core target of contemporary tissue engineering concepts. For a detailed analysis of cell-matrix interaction under highly controlled conditions, we developed(More)
The development of complex web-based information spaces faces very demanding challenges. Requirements analysis and design demands interdisciplinary modelling approaches. When using typical paper-based methods, an IT organization often experiences frustrating communication issues between teams as well as with suppliers. We present a toolkit for XML-based(More)
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