Heikki Ojala

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We increase the effective stiffness of optical tweezers by position clamping a polystyrene bead with a predictive feedback control algorithm. This algorithm mitigates the effect of feedback loop delay. Hence, higher gain than with proportional control can be employed, which results in higher effective trap stiffness, without trap instability. In experiments(More)
The simplified artificial environments in which highly complex biological systems are studied do not represent the crowded, dense, salty, and dynamic environment inside the living cell. Consequently, it is important to investigate the effect of crowding agents on DNA. We used a dual-trap optical tweezers instrument to perform force spectroscopy experiments(More)
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