Heikki Ahola

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Defects in the newly reported gene NPHS1 in chromosome 19 cause the massive proteinuria of Finnish type congenital nephrotic syndrome (CNF). Together with its gene product, nephrin, NPHS1 is providing new understanding of the pathophysiological mechanisms of glomerular filtration. Here we show the characteristic splicing of NPHS1 mRNA in the normal and CNF(More)
Nephrin is a novel transmembrane protein of kidney glomerular podocytes, which appears crucially important for the maintenance of the glomerular filtration barrier. According to its predicted structure, nephrin has additional roles in cell-cell adhesion and/or signal transduction. We have previously cloned the rat homologue of nephrin and described its(More)
Performance of the above ground (dry) biomass estimation with the medium resolution optical (ALOS AVNIR) data and radar (ALOS PALSAR) data was evaluated on a tropical forest site in Lao PDR (Laos). The average biomass of ground reference plots was relatively low, 78 t/ha, due to strong anthropogenic influence in most of the study area. The biomass estimates(More)
A papillomavirus which we designate FPV was isolated from chaffinches (Fringilla coelebs). A physical map of the FPV genome was constructed, and selected regions of this genome were studied by nucleotide sequence analysis. The results make it possible to align the FPV genome with the genome of bovine papillomavirus type 1 and to show, moreover, that avian(More)
Despite of the increased availability of genetically modified mouse strains, the experimental models in the rat have provided the most widely employed and versatile models for the study of renal pathophysiology and functional genetics. The identification of the human gene mutated in the congenital nephrotic syndrome of the Finnish type (NPHS1) has recently(More)
BACKGROUND The recently identified gene NPHS1 with its mutations causing congenital nephrotic syndrome of the Finnish type (CNF) is highly promising in providing new understanding of pathophysiology of proteinuria. Earlier we cloned a rat NPHS1 homologue, as well as characterized and raised antibodies to the respective protein product nephrin. METHODS(More)
Diabetic nephropathy is a major complication of diabetes leading to thickening of the glomerular basement membrane, glomerular hypertrophy, mesangial expansion, and overt renal disease. The pathophysiologic mechanisms of diabetic nephropathy remain poorly understood. Nephrin is a recently found podocyte protein crucial for the interpodocyte slit membrane(More)
The NPHS1 gene product, nephrin, is a crucial component of the glomerular filtration barrier preventing proteinuria and previously assumed to be kidney-specific. The aim of this study was to describe the expression of nephrin mRNA and protein in human pancreas as well as identify the nephrin-expressing cell types. RNA dot blot, reverse(More)
This paper presents a modified robust stem volume retrieval approach suitable for use with L-band SAR imagery. Multitemporal dual-polarization SAR imagery acquired by ALOS PALSAR during the summer-autumn 2007 is used in the study, along with stand-wise forest inventory data from two boreal forest sites situated in central Finland. The average sizes of(More)
ERS 1 and ASAR imagery were used for mapping the forest area of French Guiana for 1992/1993 and 2003/2004, respectively. Imagery was orthorectified using the SRTM DEM and least square algorithm was used to improve the residual geometric inaccuracies. Geometric accuracy of the ERS data using the standard VMP processor was compared with the accuracy using the(More)