Heike Spitzer

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The purpose of the Benchmark Dose Workshop was to assess the feasibility and implications of replacing the no observed adverse effect level (NOAEL) with a benchmark dose (BMD) when deriving reference doses and concentrations (RfDs and RfCs). The workshop participants supported the use of the BMD method to remove many of the limitations inherent in using the(More)
AIM This randomized, single-centre, double-blind, crossover study compared the pharmacodynamic and pharmacokinetic properties of two different doses of insulin glulisine (glulisine) and insulin lispro (lispro) in lean to obese subjects. METHODS Eighty subjects without diabetes, stratified into four body mass index (BMI) classes (<25, >or=25 to <30, >or=30(More)
To study the influence of task difficulty on the stimulus-elicited responses of inferior temporal (IT) neurons, the stimulus-elicited responses of 64 neurons were recorded from IT cortex of three rhesus monkeys while they performed three behavioral tasks — an irrelevant-stimulus task, a stimulus detection task, and a stimulus discrimination task. The monkey(More)
  • Heike Spitzer
  • Risk analysis : an official publication of the…
  • 1997
To assess the health benefits gained from the use of cleaner burning gasoline, an analysis was conducted of changes in the atmospheric concentration of eight VOCs: acetaldehyde, benzene, 1,3-butadiene, ethylbenzene, formaldehyde, POM, toluene, and xylenes resulting from the use of reformulated gasoline and oxyfuel containing the additive MTBE. Modeled(More)
The cherry-red spot in the fundus as a sign of what is now known as Tay-Sachs disease was first described by Tay in 1881 (1). The first clinical and pathological description of the condition was reported by Sachs in 1887 (2). The similarity between the morphologic and retinal changes in this condition and Niemann-Pick disease led Pick and Bielschowsky (3)(More)
The lecithins of bile and plasma from nine patients, three dogs, four rats, and two steers (oxen) were extracted and their fatty acid patterns were determined. In all four species the lecithin of bile had a higher concentration of palmitic acid than did that of plasma. The concentration of stearic and arachidonic acids was higher in plasma lecithin. These(More)