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  • Heike Meiselbach, Anselm H C Horn, Thomas Harrer, Heinrich Sticht
  • Chemistry, Medicine
  • Journal of molecular modeling
  • 2007 (First Publication: 24 January 2007)
  • AbstractDrug resistance is a very important factor contributing to the failure of current HIV therapies. The ability to understand the resistance mechanism of HIV-protease mutants may be useful inContinue Reading
  • Florian Wartha, Anselm H C Horn, Heike Meiselbach, Heinrich Sticht
  • Chemistry, Medicine
  • Journal of chemical theory and computation
  • 2005 (First Publication: 1 March 2005)
  • A major problem in the antiretroviral treatment of HIV-infections with protease-inhibitors is the emergence of resistance, resulting from the occurrence of distinct mutations within the proteaseContinue Reading
  • Nadine Homeyer, Timm Essigke, Heike Meiselbach, G. Matthias Ullmann, Heinrich Sticht
  • Chemistry, Medicine
  • Journal of molecular modeling
  • 2007 (First Publication: 6 February 2007)
  • AbstractThe serine46-phosphorylated form of the bacterial protein HPr fulfils an essential function in carbon catabolite repression (CCR). Using molecular dynamics (MD) we studied the effect of Ser46Continue Reading
  • Insa Marie Schmidt, Silvia Huebner, +13 authors K -U Eckardt
  • Medicine
  • Clinical kidney journal
  • 2019 (First Publication: 24 May 2019)
  • Abstract Background Patients with chronic kidney disease (CKD) bear a substantial burden of comorbidities leading to the prescription of multiple drugs and a risk of polypharmacy. However, data onContinue Reading
  • Natascha Schaefer, Christoph Kluck, +12 authors Carmen Villmann
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2015 (First Publication: 7 January 2015)
  • Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a range of novel glycineContinue Reading
  • Federica Fazzini, Claudia Lamina, +10 authors Florian Kronenberg
  • Medicine
  • Kidney international
  • 2019 (First Publication: 1 August 2019)
  • Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for mitochondrial dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated withContinue Reading