Heike Gerhardt

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Glial cells play a crucial role in the organization and function of the nervous system. Cell-cell adhesion receptors of the cadherin family have been shown to participate in distinct morphogenetic processes throughout the development of the CNS, but little is known about glial expression of cadherins. Applying immunofluorescence and confocal laser scanning(More)
Abstract The eye of reptiles and birds is characterized by an avascular retina and a vascular convolute called conus papillaris in reptiles and pecten oculi in birds which arises from the papilla nervi optici (PNO) or optic nerve head into the vitreous. At least in birds, this central part of the retina is the site of a heterogeneous population of glial(More)
The factors responsible for the induction and maintenance of blood-brain barrier properties are still undefined. The process of blood-brain barrier formation is thought to take place in a two-stage manner: the initial commitment of vascular sprouts by neuroectodermal cells may be followed by the stabilization of barrier properties. In the present study, we(More)
Analysis of the information obtained from more than 110 malformations of the external and middle ear operated upon by the author (Gerhardt) leads to speculation as to their course of development. Of particular interest are the varying types of stapes malformations and the influence of variations in the course of the facial nerve on the development and(More)
The major interest in the development of the blood-brain barrier and its underlying induction mechanisms is given by the crucial role they play in the maturation of the central nervous system in general. Whilst it is believed that it is the microenvironment in the brain that destines the endothelial cells to become committed to barrier properties, the(More)
Glial cells in the CNS of vertebrates serve specialized functions in close interaction with surrounding neurons and blood vessels. In the avian eye, the neural tissue (retina) and the supporting vascular structure (pecten oculi) are spatially separated and comprise distinct glial cell types, i.e., the Müller glia and the pecteneal glia, respectively. In the(More)
The stimulation of the proximal auditory nerve or the Cochlear Nuclear Complex (CNC) situated in the lateral recess of the fourth ventricle is a possibility of hearing rehabilitation for patients suffering from bilateral deafness by bilateral cerebellopontine-angle tumors or by transsections of cochlear nerves on both sides. Using such anatomical landmarks(More)
(1) The loss of hair cells after pure tone exposure at the critical level of intensity shows an exact correlation to the frequency, the time of sound exposure, and time of recovery as regards the quality and quantity. (2) The total extent of the damage of sensory cells has to be estimated higher than the hair-cell loss as observed under the light(More)
Spatially controlled in vivo sampling by contact solid phase microextraction with a non-coated silica fiber combined with gas chromatography-mass spectrometry (GC-MS) was utilized for hydrocarbon profiling in tarsal adhesion secretions of four insect species (Nicrophorus vespilloides, Nicrophorus nepalensis, Sagra femorata, and Gromphadorhina portentosa) by(More)