Heidy Pérez

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The present study was undertaken to demonstrate the presence of bradykinin B1 receptors mediating contraction of human umbilical vein. The bradykinin B1 receptor selective agonist, des-Arg9-bradykinin, produced a dose-dependent contractile response of human umbilical vein rings. Furthermore, des-Arga-bradykinin-mediated response increased in a(More)
Two Leishmania strains, AZV (isolated from a typical case of American cutaneous leishmaniasis) and AMP (from a case of diffuse cutaneous leishmaniasis), were studied in C57BL/6 and BALB/c mice. After infection with 10(4) amastigotes of either strain, C57BL/6 mice developed self-resolving lesions lasting 20 to 23 weeks and showed both delayed(More)
BALB/c mice infected with Leishmania mexicana developed a chronic infection usually accompanied by the appearance of metastatic lesions. Throughout the 20 weeks of observation, infected mice ;howed an impairment in both in vivo delayed hypersensitivity response and in vitro lymphocyte reactivity to leishmanial antigen. Four to 8 weeks after inoculation(More)
C57BL/6 mice infected with Leishmania mexicana showed depression of the in vitro immunoglobulin M-plaque-forming cell response to sheep erythrocytes. Immunodepression was present 3 weeks after inoculation and was maximal at 11 weeks. Thereafter, there was a gradual return to normal immunoresponsiveness correlated with the resolution of lesions. At the time(More)
The course of cutaneous infection with Leishmania mexicana was studied in normally nourished and protein deprived C57Bl/6 mice. Mice fed a normal diet showed self-resolving lesions and produced cellular and humoral responses against the parasite. In contrast, mice fed a protein deficient diet which developed chronic protein calorie deficiency failed to(More)
Symbiotic, a combination of short chains-carbohydrates with prebiotic properties e.g. fructooligosaccharides (FOS) and biotherapeutical microorganisms, provides positive health effects and well-being in humans and animals. However; the lack of accurate screening methods hampers the possibility to get new fructo-oligosaccharides (FOS)-fermenting yeast or(More)
Protein deprived C57BL/6 mice infected with 10(3) amastigotes of Leishmania mexicana showed early arrest of lesion progression during the first 5 weeks of infection with subsequent development of progressive non-healing lesions. In contrast, well nourished mice similarly infected developed gradual healing lesions. The early resistance of malnourished mice(More)