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PURPOSE To describe the baseline findings in patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. METHODS This is a longitudinal observational study of 1209 patients with keratoconus enrolled at 16 clinical centers. Its main outcome measures are corneal scarring, visual acuity, keratometry, and quality of life. (More)
The Wnt/β-catenin response pathway is central to many developmental processes. Here, we assessed the role of Wnt signaling in early eye development using the mouse as a model system. We showed that the surface ectoderm region that includes the lens placode expressed 12 out of 19 possible Wnt ligands. When these activities were suppressed by conditional(More)
PURPOSE To describe age and other risk factors for corneal infiltrative and inflammatory events (CIEs) in young, soft contact lens (SCL) wearers and to model the age-related risk. METHODS A multicenter, retrospective chart review of 3549 SCL wearers (8-33 years at first observed visit, +8.00 to -12.00D, oversampling <18 years) captured CIEs from January(More)
The United States military relies on visual acuity standards to assess enlistment induction and military occupational specialty eligibility, as well as to monitor soldiers' combat vision readiness. However, these vision standards are not evidence based and may not accurately reflect appropriate standards for military readiness or reflect a correlation(More)
  • Chalmers, Chalmers Rl, H Wagner, Mitchell Gl
  • 2013
1 suggest that there could be a sizeable increase in number of myopic children and teens who wear contact lenses in the near future. This is because the results of early trials on children have shown that it may be possible to slow the progression of myopia by using contact lenses that correct peripheral refractive error. If this demand materializes it will(More)
PURPOSE The purpose of this study is to compare the efficacy of usual care to an intervention emphasizing patient education targeted at a multicultural adult patient population with diabetes seeking eye care in an academic health center. METHODS Ninety patients were randomized to usual care or to the intervention. All patients received a comprehensive eye(More)
PURPOSE The purpose of this study was to assess risk factors associated with soft contact lens (SCL)-related corneal infiltrative events (CIEs). METHODS This was a single-visit, case-control study conducted at five academic centers in North America. Cases were defined as current SCL wearers with a symptomatic CIE. For each case, three age- and sex-matched(More)
OBJECTIVES To investigate how add power affects binocular distance visual acuity in subjects wearing simultaneous vision, balanced progressive, multifocal contact lenses. METHODS Twenty-five young normally sighted subjects were fit binocularly, according to the manufacturers' fitting nomogram, with CooperVision Proclear Multifocal contact lenses. A(More)
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