Heidi Theil Hansen

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BACKGROUND Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often unconvincing because the size of the test set is typically small. To overcome this problem we used publicly available breast cancer gene(More)
INTRODUCTION Predicting the clinical course of breast cancer is often difficult because it is a diverse disease comprised of many biological subtypes. Gene expression profiling by microarray analysis has identified breast cancer signatures that are important for prognosis and treatment. In the current article, we use microarray analysis and a real-time(More)
In fission yeast, centromeric heterochromatin is necessary for the fidelity of chromosome segregation. Propagation of heterochromatin in dividing cells requires RNA interference (RNAi) and transcription of centromeric repeats by RNA polymerase II during the S phase of the cell cycle. We found that the Med8-Med18-Med20 submodule of the Mediator complex is(More)
Post-transcriptional RNA regulons ensure coordinated expression of monocistronic mRNAs encoding functionally related proteins. In this study, we employ a combination of RIP-seq and short- and long-wave individual-nucleotide resolution crosslinking and immunoprecipitation (iCLIP) technologies in Drosophila cells to identify transcripts associated with(More)
  • Ben-David Merav, Dave Mcdonald, Steve Miller, Frank Rahel, Kaithryn E Ott, Aaron Specifically +26 others
  • 2009
ii Acknowledgements I believe the longer you stay in one place the more people you will be indebted to; consequently I have a great number of people to thank. First I must thank my committee members Drs. Merav Ben-David, Dave McDonald and Steve Miller for their invaluable insight and assistance, and also for their patience. I am especially grateful to Merav(More)
Word count = 8,623 (including references, tables, and figure legends) 33 34 2 ABSTRACT 1 Many studies have evaluated why males in mammals form social groups and the 2 associated costs and benefits; few however, have investigated how these groups are 3 formed and maintained. In this study, we observed behavioural interactions of 15 male 4 coastal river(More)
Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way(More)
The molecular portraits of breast tumors are conserved across microarray platforms. Abstract Background: Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often unconvincing because the size of the test set(More)
  • Merav Ben-David, Howard Golden, Michael Goldstein, Forest Service, Ian Martin, Kenai Fjords +8 others
  • 2004
The goals of this study were: 1. To establish baseline information on the distribution, relative abundance, and minimum number alive of river otters in Kenai Fjords National Park (KFNP) using latrine site surveys and DNA fingerprinting of fecal samples. 2. To establish baseline information on the distribution, relative abundance, and minimum number alive of(More)